53 healthy women who had been amenorrhea for at least 1 year were randomly assigned to cyclic, sequential hormone regimen for 6 months. They received 0.625 mg conjugated equine estrogen(CEE; PremarinR), respectively, from days 1-25 and 5 mg
medroxyprogesterone acetate (MPA; ProveraR) from days 16~25. Hormonal replacement therapy had favorable effects on lipid metabolism.
After 6 months treatment, high density lipoprotein (HDL) cholesterol level and triglyceride increased 16% and 28% compared with pretreatment values, respectively.
The findings of this study on the relative effects of hormonal replacement therapy, administered sequentially, on lipid metabolism provide guidelines for the treatment of postmenopausal women.
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